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Addressing Sample Contamination with Low-Extractable EPDM Vial Septa
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However, even when appropriately labeled, single-dose vials that contain 81 significantly. 8 more drug than is required for a single dose may result in the misuse of the leftover 82 drug product. Similarly, the need to combine several single-dose vials for a single patient dose 83 may lead to medication errors and microbial contamination.
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extractables and leachables contaminating the drug product. Siliconized stoppers also tend to stick to the freeze dryer shelf (Figure 2). The degree of stoppers sticking to the shelf is dependent on the compression force of the stoppering ram and the duration of compression. Factors to Consider While Selecting Stoppers for Lyophilized Vials
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Jan 27, 2021 · If it is a constant background contamination of certain masses, such as showing up even in a tune, it is septa material in the system. By removing the syringe and performing an injection, you will have a quick test to see if the contamination is in the system or coming from something the syringe is either passing through or pulling solution from.
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Jul 10, 2012 · Moreover, Septum D performance is generally superior to the other septa. Septum C bleeds even at 100°C, suggesting its unsuitability in routine high-temperature GC–MS studies. Significantly, all septa used in this study bleed phthalate compounds at much lower IP temperature, contrary to the respective manufacturers’ claims on quality and
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autosamplers withdrawing greater than 50µL of sample from a 2mL vial. Polyethylene (PE) Septa: Polyethylene septa are offered as single piece caps where the septum is molded as a part of the cap. The surface for needle penetration is 0.01” thick allowing for use with thin gauge needles. Polyethylene septa are not resealable and intended
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A sample of the septa was taken and placed into an extraction solution, heated, and the resulting supernatant analyzed by GC. There is a marked difference between the two sources of septa. The poor quality (often cheaper) septa clearly shows the presence of some impurities, siloxanes. These impurities are absent from the PerkinElmer septa sample.
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Dec 11, 2018 · contamination, a trip blank prepared from organic-free reagent water (as defined in Chapter One) should be maintained with the samples throughout sampling, shipping, and storage. Including activated carbon in the bags containing the sample vials may help reduce concerns related to these potential sources of sample contamination.
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This document will provide you with the technical guidance you need in order to make the right selection. Choosing the right septa When selecting which septa is right for your experiments, it is important to consider the following:
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The septum you choose for your autosampler vial can impact sample evaporation, sample security, needle bending and blockages, and instrument down time. Don’t let the complexities of septa selection slow you down.
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Feb 25, 2021 · To meet these demands for low detection limits, your LC/MS flow path should be uncontaminated by perfluorinated compounds (PFC). Aijiren . PFC-free vials and caps are uniquely designed to prevent undesired . background PFC contamination and coelution. – Protect sample integrity. Aijiren PFC-free vials and caps will not compromise your analysis.
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Aptar Pharma’s Small Volume Parenteral Stoppers (Serum Stoppers) are designed for blowback and non-blowback vials and provide optimal protection and drug delivery. Our range of pharmaceutical rubber Serum Stoppers are designed to meet multiple-piercing needs and facilitate manufacturing processes. Discover our Vial containment solutions and
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the process flow. Thus, MicroLiter autosampler vials, caps, septa and inserts are available in a variety of formats, individually, component kits or assembled kits. • Vials with Limited Volume Inserts installed decreases the prep time per sample. • Component kits offer the convenience of one product number for the vial cap and septa.
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Jun 9, 2022 · Siloxane contamination can interfere with low-level analysis of target compounds whether they are discrete peaks or manifested as high background bleed. They are one of the most common types of “ghost peaks” in gas chromatography (GC) and can come from a variety of sources such as inlet septa, columns, valves, solvents, and vial cap seals.
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This barrier protects your sample from external contamination while allowing a needle (from a manual or automatic syringe) to enter the vial, and extract the sample for the next stage of separation. Choosing the correct septum material is vital, as it will interact with the analyte in your sample matrix as well as the sampler needle.
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